转-Globin digest, acidic protease hydrolysate, inhibits dietary hypertriglyceridemia and Val-Val-Tyr-
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-3VXJN3R-13&_user=10&_coverDate=04%2F12%2F1996&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1526565443&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e214d0a290448e0cd9d837a5aa378482&searchtype=a
Kyoichi Kagawa, Hisako Matsutaka, Chizuko Fukuhama, Yukiko Watanabe and Hiroaki Fujino
Pharmacological Laboratory, Hankyu-Kyoei Bussan Co., Ltd., Osaka 563, Japan
Revised 18 March 1996. Available online 2 March 1999.
Abstract
Globin digest (GD), prepared from globin by acidic protease treatment, suppressed the elevation of serum triglyceride level in not only total but also chylomicron fraction after oral administration of olive oil By screening with this lowering activity, we concluded that Val-Val-Tyr-Pro (VVYP) would be most effective constituent having hypotriglyceridemic action in GD The mode of their action was dose dependent and did not show species specificity Neither the repression of peristaltic movement of intestine nor the delaying of gastric emptying was caused by intake of GD or VVYP, however, the excretion of administered lipid was much more than that of control. Furthermore, administration of GD caused more prominent activation of hepatic triglyceride lipase (HTGL) and the increase of hepatic free fatty acid (FFA) concentration in early phase after administration of fat. From these results, it could be elucidated that GD, and also VVYP, inhibited fat absorption from digestive tract and enhanced activity of HTGL, so that more rapid clearance of dietary hypertriglyceridemia was caused.
Author Keywords: globin digest; Val-Val-Tyr-Pro; oligopeptide; hypotriglyceridemic effect; hepatic triglyceride lipase
Article Outline
• References
Corresponding author. Send correspondence to: Kyoichi Kagawa, Ph. D., Pharmacological Laboratory, Hankyu-Kyoei Bussan Co., Ltd, Furue-Cho 180, Ikeda, , Osaka 563, , Japan Phone: 80-727-51-9225, FAX: 80-727-51-9725.
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Life Sciences
Volume 58, Issue 20, 12 April 1996, Pages 1745-1755
Kyoichi Kagawa, Hisako Matsutaka, Chizuko Fukuhama, Yukiko Watanabe and Hiroaki Fujino
Pharmacological Laboratory, Hankyu-Kyoei Bussan Co., Ltd., Osaka 563, Japan
Revised 18 March 1996. Available online 2 March 1999.
Abstract
Globin digest (GD), prepared from globin by acidic protease treatment, suppressed the elevation of serum triglyceride level in not only total but also chylomicron fraction after oral administration of olive oil By screening with this lowering activity, we concluded that Val-Val-Tyr-Pro (VVYP) would be most effective constituent having hypotriglyceridemic action in GD The mode of their action was dose dependent and did not show species specificity Neither the repression of peristaltic movement of intestine nor the delaying of gastric emptying was caused by intake of GD or VVYP, however, the excretion of administered lipid was much more than that of control. Furthermore, administration of GD caused more prominent activation of hepatic triglyceride lipase (HTGL) and the increase of hepatic free fatty acid (FFA) concentration in early phase after administration of fat. From these results, it could be elucidated that GD, and also VVYP, inhibited fat absorption from digestive tract and enhanced activity of HTGL, so that more rapid clearance of dietary hypertriglyceridemia was caused.
Author Keywords: globin digest; Val-Val-Tyr-Pro; oligopeptide; hypotriglyceridemic effect; hepatic triglyceride lipase
Article Outline
• References
Corresponding author. Send correspondence to: Kyoichi Kagawa, Ph. D., Pharmacological Laboratory, Hankyu-Kyoei Bussan Co., Ltd, Furue-Cho 180, Ikeda, , Osaka 563, , Japan Phone: 80-727-51-9225, FAX: 80-727-51-9725.
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Life Sciences
Volume 58, Issue 20, 12 April 1996, Pages 1745-1755
