Lone Survivor is a post-apocalyptic survival horror game with retro-styled 2D graphics. Players control a man in a surgical mask. This character is an isolated survivor of an infection which has turned the world's population into aggressive, shambling mutants. With limited food and an increasingly fragile mental state, the player character must be guided outside his apartment to scavenge and explore. There are no indications that any other survivors exist except for a note which states that there are other survivors on the opposite side of the apartment building.